Staff & Leadership

Eric Seaberg, PhD

Eric Seaberg, PhD - Photo

Biography

Assistant Professor
Department of Epidemiology, Bloomberg School of Public Health
The Johns Hopkins University

Research interests

Epidemiologic methods, cohort studies, case-control studies, nested studies, longitudinal data analysis, survival analysis, HIV/AIDS, chronic disease burden and progression in the context of HIV, viral hepatitis, cognitive impairment and dementia, and neurodevelopment, liver disease, and pulmonary function in children

Methods of expertise

Dr. Seaberg has both epidemiologic and biostatistical expertise with the design and analysis of studies focusing on the incidence and course of chronic diseases among people infected with HIV.  He developed and executed a variety of observational (cross-sectional, case-control, and longitudinal) cohort studies within the MACS/WIHS Combined Cohort Study (MWCCS) that is coordinated at the Bloomberg School of Public Health.  Additionally, he served as co-chair of the WIHS Malignancy Working Group and is currently the PI of a neuroimaging study to exam the effects of HIV on brain structure and function

Services available to CFAR investigators

Design and development of research protocols for observational studies, linking investigators with experts in the epidemiology of HIV, mentoring young investigators who are planning and executing epidemiological studies including data management and quality control issues and the interpretation of study findings in the context of HIV literature. 

Sample Papers

  1. ​Wang Z, Cheng Y, Seaberg EC, Becker JT. Quantifying Diagnostic Accuracy Improvement of New Biomarkers for Competing Risk Outcomes. Biostatistics 2020 [In press].
    1. The net reclassification improvement (NRI) and the integrated discrimination improvement (IDI) indices are used to evaluate the improvement in predicting outcomes when new biomarker data become available.This paper extends the NRI and IDI to the context of competing risks.
  2. Popov M, Molsberry SA, Lecci F, Junker B, Kingsley LA, Levine A, Martin E, Miller E, Munro CA, Ragin A, Seaberg E, Sacktor N, Becker JT. Brain Structural Correlates of Cognitive Trajectories in HIV Disease. Brain Imaging Behav 2020;14(3):821-829. PMC6616021.
    1. Trajectories to cognitive impairment in HIV disease are the result, in part, of the structural integrity of brain regions linked to HIV disease (basal ganglia), as well as cortical regions linked with normal and pathological aging (cingulate cortex), suggesting that cognitive morbidity may be predicted using patterns of CNS atrophy.
  3. Rubin LH, Springer G, Martin EM, Seaberg EC, Sacktor NC, Levine A, Valcour VG, Young MA, Becker JT, Maki PM. Elevated depressive symptoms are a stronger predictor of executive dysfunction in HIV-infected women than men. J Acquir Immune Defic Syndr 2019;81(3):274-283. PMC7254882
    1. Depression contributes to cognitive impairment across a broad range of cognitive domains in HIV+ and HIV- individuals, but HIV+ depressed women show greater vulnerabilities in executive function. Treating depression may help to improve cognition in patients with HIV infection.
  4. Price JC, Seaberg EC, Storsor V, Witt MD, Lellock CD, Thio CL. AST-to-Platelet Ratio Index Increases Significantly 3 Years Prior to Liver-Related Death in HIV-Hepatitis-Coinfected Men. AIDS 2018;32(5):653-661. PMC6251714
    1. We compared APRI up to 9 years before liver-related death among viral hepatitis-infected men (91% HIV+) to matched controls. APRI was stable among controls but among cases increased 4.6%/year from 9 to 3 years pre-death (p=0.10) and 30%/year during the 3 years pre-death (p<0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis coinfection.
  5. Seaberg EC, Witt MD, Jacobson LP, Detels R, Rinaldo CR, Young S, Phair JP, Thio CL. Spontaneous Clearance of the Hepatitis C Virus Among Men Who Have Sex With Men. Clin Infect Dis 2015;61(9):1381-1388. PMC4599393.
    1. High spontaneous HCV clearance coupled with the lack of an association between the rs12979860 SNP and spontaneous clearance among MSM who do not use injection drugs suggests that the immune mechanisms involved with a successful response to acute HCV differ by mode of virus acquisition.

Links

JHSPH:  http://www.jhsph.edu/faculty/directory/profile/988/eric-seaberg

My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47827067/?sort=date&direction=descending

Multicenter AIDS Cohort Study:  http://aidscohortstudy.org/

Women’s Interagency HIV Study:  https://statepi.jhsph.edu/wihs/wordpress/

MACS/WIHS Combined Cohort Study: https://mwccs.org/