Scott Kitchen, PhD, Director
skitchen@ucla.edu
(310) 983-1251
The humanized mouse core lab provides the infrastructure, materials, animals, technical expertise and support that facilitates the use of humanized immunodeficient mice in studies examining the pathogenesis and treatment of HIV-disease. Recent advances have enabled the recapitulation of human immune cell development and function in immunodeficient mice. Human hematopoietic tissue is placed in the mice where it undergoes multilineage hematopoiesis into multiple types of human immune cells. The core provides a variety of different humanized mouse models, including the BLT model, the SCID-hu model, the huPBL-SCID model, the HIS mouse model, and the CD34-NSG model, amongst others, to support AIDS-related investigation.
